Limantara, Leenawaty and Indrawati, Renny and Wijaya, Dian Ekawati and Sulistiawati, Erni and Suparto, Irma Herawati and Wijayanti, Retno Dumilah Esti and Brotosudarmo, Tatas Hardo Panintingjati (2017) Hypocholesterolemic Effect and Pigments Composition of Herbal Medicine Containing Higher and Lower Plants. International Journal of Pharmacy and Pharmaceutical Sciences, 9 (11). pp. 97-103.
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Abstract
Objective: The objective of this research was to investigate the antihypercholesterolemic activity of herbal medicine which consisted of pigmentrich simplicia from higher and lower plants, as well as to determine its pigments composition. Methods: Sprague-Dawley male rats were randomly divided into five cholesterol-rich diet groups as well as one negative control group with a normal diet, in order to investigate its effect on plasma lipid. The new herbal formulation was administered orally to induced-rats at three dosage levels, whereas simvastatin was used as a comparable generic drug. Pigments composition was determined by means of reversed-phase high performance liquid chromatography (HPLC) using gradient protocol, monitored with diode array detector at 430 nm. Results: The administration of herbal medicine was able to significantly reduce total plasma cholesterol and low-density lipoprotein-cholesterol (p<0.05) at a dose of 312.5 mg/kg of body weight/day compared to positive control group, and hence the atherogenic index was also lowered. The chromatographic analysis of pigments determination and quantification are reported correspondingly to support the possible active compounds data of hypocholesterolemic property. Conclusion: The results obtained in this research work indicated the potency of pigment-rich lower plants to substitute the obtrusive exploration and dominant use of higher plants for treating dyslipidemia.
| Item Type: | Artikel |
|---|---|
| Uncontrolled Keywords: | Herbal medicine, Lower plants, pigments, Cholesterol, Rats |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Fakultas Teknologi dan Desain > Teknik Sipil |
| Depositing User: | Admin Repository |
| Date Deposited: | 17 Apr 2020 16:10 |
| Last Modified: | 02 Jun 2022 06:20 |
| URI: | http://eprints.upj.ac.id/id/eprint/107 |
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