Limantara, Leenawaty and Koehler, Peter and Wilhelm, Brigitte and Porra, Robert J and Scheer, Hugo (2006) Photostability of Bacteriochlorophyll a and Derivaties: Potential Sensitizers for Photodynamic Tumor Therapy. Photochemistry and Photobiology, 82 (3). pp. 770-780.
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The photostabilities of bacteriochlorophyll a and several of its derivatives, which are of interest as potential sensitizers in photodynamic tumor therapy, were investigated. The pigments were irradiated with light >630 nm in organic solvents (acetone, tetrahydrofuran, pyridine, methanol, ethanol, n-propanol, 2-propanol and toluene) and in aqueous detergent solutions (cetyl-trimethyl-ammonium bromide [CTAB], lauryldimethyl-aminoxide [LDAO] or sodium dodecyl-sulfate [SDS] and Triton X-100 [TX100]). Their stabilities in these different solvents were determined in the presence and absence of an external sensitizer (pyromethyl-pheophorbide a), oxygen, sodium ascorbate and inert gas (Ar) or vacuum. The photodegradation products of bacteriochlorophyll a in acetone solution were isolated, purified by HPLC and analyzed by their absorption spectra and mass spectroscopy. Besides the well-known dehydrogenation products, such as [3-acetyl]-chlorophyll a, which were obtained as by-products, the major products had low absorption in the visible-near infrared spectral range. The spectral signature of the major component of these products was characteristic of linear open-chain tetrapyrroles, but they lacked the characteristic protonation-deprotonation behavior and reactivity of bilins with Zn(++).
| Item Type: | Artikel |
|---|---|
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Fakultas Teknologi dan Desain > Teknik Sipil |
| Depositing User: | Admin Repository |
| Date Deposited: | 15 Apr 2020 10:44 |
| Last Modified: | 03 Jun 2022 02:39 |
| URI: | http://eprints.upj.ac.id/id/eprint/90 |
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